COPD and Genetics: Genes That Could Increase Your Risk

by | Aug 17, 2019 | Blog, COPD

Smoking is one of the primary reasons people get chronic obstructive pulmonary disease (COPD) and other chronic lung diseases. However, there is a growing body of evidence that suggests your genetics may play a role as well.

I’m Dr. Perry at Lung Health Institute, and I want to help you understand which genes could be increasing your risk of developing COPD.

Is COPD a Genetic Condition?

Of all the people who smoke, about 1 in 4 ends up with COPD or another chronic lung disease according to 1 research study. This statistic led some doctors to believe that chronic lung diseases might have a genetic component, and several studies have found genes that seem to increase the likelihood of COPD.


The TGFB gene is responsible for helping to create several molecules that affect the body. For instance, it aids in the creation of activin, which is a molecule involved in the body’s natural inflammatory responses. If the TGFB gene is damaged or mutated in some way, this could lead to increased activin production and increased likelihood of lung inflammation.

FAM13A Gene

FAM13A is a gene that’s typically present in lung tissue cells of patients with COPD, according to a 2016 study. This gene is thought to increase COPD likelihood by promoting the degradation of the protein catenin in the lung tissues.

Genetic Markers of COPD

A genetic marker is a small part of a DNA strand that’s used to identify or locate specific genes. The most common genetic marker that indicates an increased likelihood of developing COPD is found on the alpha-1 antitrypsin (A1AT) gene. A study showed that constructions of this gene that contain lysine in place of glutamine may indicate an increased COPD risk. The same study reported that A1AT genes that have valine in place of certain glutamines can also be an indication that you’re at increased risk of COPD.

As further studies are performed, geneticists may learn more about the genetic particulars of COPD and other chronic lung diseases. This may help in the early detection and treatment of these diseases.

Lung Health Institute Offers Several Treatment Options for COPD

Lung Health Institute has developed several natural treatment options for patients with chronic lung conditions like COPD. We offer Anti-Inflammatory Initiative™ (AI²™) plans that are designed to train the body to use fats to fight inflammation and boost the immune system. We also offer minimally invasive cellular therapy, a procedure intended to reduce inflammation and promote healing in lung tissue using cells from your own blood.

Take the next step to Breathe Easier™. Contact one of our patient coordinators today for more information or to schedule a free consultation.

Contact Us

Call Toll-Free: 888-745-6697


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